Programme
Wednesday, 20.03.2013
| 08:00-10:00 | Registration |
| 10:00-10:15 | Welcome (Petra Boukamp, Otmar Wiestler, Rainer Engers) |
| 10:30-12:00 | Symposium 1: Invasion and metastasis: a
different “point of view” - Imaging cancer invasion
and therapy Chair: Rainer Engers, Matthias Dobbelstein |
| 10:30-11:00 | Targeting cancer invasion and therapy resistance (Peter Friedl) |
| 11:00-11:30 | Seeing is believing is understanding: real-time
microscopy of brain tumor progression and response
to therapies (Frank Winkler) |
| 11:30-11:45 | Anti-tumor effects of peptide hormone analogs in
pheochromocytoma cell lines and preclinical tumor
imaging (Martin Ullrich) |
| 11:45-12:00 | Bevacizumab treatment of HER2 expressing
xenograft prevents uptake of fluorescent labeled
Trastuzumab: Correlation of in vivo fluorescence
imaging with multispectral 3D ultramicroscopy (Michael Dobosz) |
| 12:00-13:30 | Lunch Break |
| 13:30-15:00 | Symposium 1 continued: Invasion and
metastasis: a different “point of view” - Tracing
metastatic cancer Chair: Nils Cordes, Rainer Engers |
| 13:30-14:00 | Circulating tumor cells in cancer patients:
Biology and clinical implications (Klaus Pantel) |
| 14:00-14:30 | Metastasis from a radiation oncologist point of
view (Amir Abdollahi) |
| 14:30-14:45 | A complex interplay between CD44, the ECM,
G-Protein-coupled receptors and Receptor Tyrosine
Kinases in tumor progression (Véronique Orian-Rousseau) |
| 14:45-15:00 | Few genes are associated with the capability of
pancreatic ductal adenocarcinoma cells to grow in
the liver of nude rats (Hassan Adwan) |
| 15:00-17:30 | Poster Session 1 and coffee |
| 17:30-19:00 | Symposium 2: Targeting heterogeneous
Breast Cancer Chair: Lisa Wiesmüller, Roland Moll |
| 17:30-18:00 | Triple negative breast cancer: Subtypes,
molecular targets, and therapeutic apporaches (Jennifer Pietenpol) |
| 18:00-18:30 | Receptor tyrosine kinases in breast cancer: from
mechanisms to therapeutic targeting (Nancy Hynes) |
| 18:30-18:45 | EZH2 regulates the heterogenic composition of
basal-like breast cancer cell populations (Ittai Ben-Porath) |
| 18:45-19:00 | Development of inhibitors targeting p130Cas as
novel therapeutics for breast cancer (Joerg Kumbrink) |
| 19:30 | Welcome Reception „Wine & Cheese“ |
Thursday, 21.03.2013
| 08:30-10:00 | Symposium 3: Dissecting cancer genomes
and epi-genomes Chair: Martin Lipp, Peter Lichter |
| 08:30-09:00 | Dissecting the genome complexity underlying
pediatric brain tumors (Peter Lichter) |
| 09:00-09:30 | Probing the cancer methylome (Stephan Beck) |
| 09:30-09:45 | Global DNA methylation signature of HPV-related
oropharyngeal squamous cell carcinoma (Jochen Hess) |
| 09:45-10:00 | UVA/UVB-induced epigenetic regulation of tumor
suppressor and miRNA gene expression (Ruediger Greinert) |
| 10:00-10:15 | Coffee Break |
| 10:15-11:30 | Hunting the elusive oncogene: a stroke
of good luck (Bob Weinberg) |
| 11:30-12:30 | Cancer Award |
| 12:30-14:00 | Lunch Break |
| 14:00-15:30 | Symposium 4: Modelling of oncogenic
pathways on the way to clinical pay-off? Chair: Klaus-Peter Janssen, Reinhold Schäfer |
| 14:00-14:30 | Genome analysis, computer modelling and
personalized cancer treatment (Ralf Herwig) |
| 14:30-15:00 | Reverse engineering transcriptional networks in
cancer cells (Reinhold Schäfer) |
| 15:00-15:15 | DNA-methylome analysis of mouse intestinal
adenoma identifies a tumour-specific signature that
is partly conserved in human colon cancer (Markus Morkel) |
| 15:15-15:30 | Strong negative feedback from Erk to Raf confers
robustness to MAPK signallin (Christine Sers) |
| 15:30-17:00 | Poster Session 2 and coffee |
| 17:00-18:30 | Symposium 5: Closing in on the ultimate
culprits: the tumor cells and its neighbourhood -
Regulatory faults in the tumor cell Chair: Michael Schwarz, Martin Eilers |
| 17:00-17:30 | Targeting Myc and N-Myc for Tumor Therapy (Martin Eilers) |
| 17:30-18:00 | Oncogene-mediated alterations in chromatin
conformation (Mark Rubin) |
| 18:00-18:15 | Galectin-8 as a new modulator of K-Ras-induced
signaling in carcinoma cell (Klaudia Giehl) |
| 18:15-18:30 | Degradation of macrophage-colony stimulating
factor receptor, c-Fms, in epithelial cancer cells
is enhanced by induction of autophagy (Alexandra Koch) |
| 18:30-19:30 | AEK Member Assembly |
| 20:00 | Social Get-together |
Friday, 22.03.2013
| 08:30-10:00 | Symposium 5 continued: - The many faces
of the tumor environment Chair: Jürgen Becker, Holger Kalthoff |
| 08:30-09:00 | Cytoprotective signalling pathways in tissue
repair and cancer (Sabine Werner) |
| 09:00-09:30 | Remodeling and homeostasis of the extracellular
matrix: implications for fibrotic diseases and
cancer (Janine T. Erler) |
| 09:30-09:45 | Remodelling of the lymphoma-stroma interface
within secondary lymphoid organs involves
fibroblastic reticular cells and dendritic cells
(Uta Elisabeth Höpken) |
| 09:45-10:00 | A genetic mouse model to identify the role of
the immune adapter protein MyD88 in colorectal
cancer (Anne Holtorf) |
| 10:00-10:30 | Coffee Break |
| 10:30-12:00 | Symposium 5 continued Chair: Klaus Bosslet, Winfried Wels |
| 10:30-11:00 | Extracellular trafficking of oncogenes -
therapeutic and diagnostic implications (Janusz Rak) |
| 11:00-11:15 | Humanized tumor mice – a new model to
investigate and improve cancer therapy (Anja Kathrin Wege) |
| 11:15-11:30 | Towards multi-scale modelling of the patient
individual tumor microenvironment (Niels Grabe) |
| 11:30-12:00 | Immunogenic cell death fingerprinting for the
detection of adjuvants in cancer therapy (Oliver Kepp) |
| 12:00-13:30 | Lunch Break |
| 13:30-14:30 | Key-note Lecture: Why don't we get more
cancer? A proposed role of the microenvironment in
restraining cancer progression Chair: Petra Boukamp (Mina Bissell) |
| 14:30-14:45 | Short Break |
| 14:45-16:00 | Symposium 6: Targeted therapy- melanoma
a success story? Chair: Cornelia Mauch, Jens Hoffmann |
| 14:45-15:15 | BRAF Inhibitors and beyond (Meenhard Herlyn) |
| 15:15-15:45 | Natural circulating plasmacytoid dendritic
cells: Key for antitumor immunity? (Jolanda de Vries) |
| 15:45-16:00 | Preclinical study of combined non-viral gene-
and chemotherapy of malignant melanoma (Wolfgang Walther) |
| 16:00 | Poster Prizes and concluding remarks |